Itachi was rarely hungry. Whether it was due to disease, his own body gradually approaching its end or a learned fear of side effects from treatment, he didn't know anymore. Without separate medicine to deal with the nausea at first, he often found himself having to choose between treatment and food. Or having that choice unpleasantly made for him.

He admitted as much to Renji.

The medic could probably have guessed as much. Itachi was very thin. Too thin, really, for his own good.

"I'd normally ask for a little tea... but I don't want anything that warm right now. Thank you, though..."